Our team has published several high impact research papers on many core technology advances in the field.
A new anti-mesothelin antibody targets selectively the membrane-associated form.
Publication: MAbs. 2017 Apr;9(3):567-577. doi: 10.1080/19420862.2017.1288770. Authors: Asgarov K, Balland J, Tirole C, Bouard A, Mougey V, Ramos D, Barroso A, Zangiacomi V, Jary M, Kim S, Gonzalez-Pajuelo M, Royer B, de Haard H, Clark A, Wijdenes J, Borg C.
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.
Publication: Nat Med. 2017 Sep;23(9):1086-1094. doi: 10.1038/nm.4390. Epub 2017 Aug 21. Authors: Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AVH, Zanoni P, Landro JA, Barucci N, Zavadoski WJ, Sun Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M,...
A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing
Publication: mAbs. June 2019. doi:10.1080/19420862.2019.1618673 PMID: 31107136. Authors: Parthiban K, Perera RL, Sattar M, Huang Y, Masters E, Griffiths D, Surade S, Leah R, Dyson MR, McCafferty J Download Publication
Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?
Publication: BMJ Journals. December 2018, 78 (2). doi:10.1136/annrheumdis-2018-214294 PMID: 30552174. Authors: Susan R Aungier, Alison J Cartwright, Anja Schwenzer, Jennifer L Marshall , Michael R Dyson, Peter Slavny, Kothai Parthiban, Aneesh Karatt Vellatt, Ilfita...
In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies
Publication: Nature Communications. October 2018. doi:10.1038/s41467-018-06086-4 PMID: 30279409. Authors: Laustsen AH, Karatt-Vellatt A, Masters EW, Arias AS, Pus U, Knudsen C, Oscoz S, Slavny P, Griffiths DT, Luther AM, Leah RA, Lindholm M, Lomonte B, Gutiérrez JM,...
Basics of Antibody Phage Display Technology
Publication: Toxins (Basel). June 2018. doi:10.3390/toxins10060236 PMID: 29890762. Authors: Ledsgaard L, Kilstrup M, Karatt-Vellatt A, McCafferty J, Laustsen AH
Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from ligand binding domain
Publication: Scientific Reports. August 2017. PMID: 28827556. Authors: DiCara DM, Chirgadze DY, Pope AR, Karatt-Vellat A, Winter A, Slavny P, van den Heuvel J, Parthiban K, Holland J, Packman LC, Birchmeier W, Gherardi E, McCafferty J
Fundamentals of Expression in Mammalian cells
Publication: Adv Exp Med Biol.. May 2016, 896 (217-24). PMID: 27165328. Authors: Dyson MR
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo
Publication: Oncotarget. March 2016, 29 (7): 16773-92 PMID: 26934448. Authors: Botkjaer KA, Kwok HF, Terp MG, Karatt-Vellatt A, Santamaria S, McCafferty J, Andreasen PA, Itoh Y, Ditzel HJ, Murphy G
The INNs and outs of antibody nonproprietary names
Publication: MAbs. January 2016, 8 (1): 1-9 PMID: 26716992. Authors: Jones TD, Carter PJ, Plückthun A, Vásquez M, Holgate RG, Hötzel I, Popplewell AG, Parren PW, Enzelberger M, Rademaker HJ, Clark MR, Lowe DC, Dahiyat BI, Smith V, Lambert JM, Wu H, Reilly M, Haurum...
