Our team has published several high impact research papers on many core technology advances in the field.
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Selection of Antibodies Interfering with Cell Surface Receptor Signaling Using Embryonic Stem Cell Differentiation
Publication: Methods Mol. Biol. January 2016. 1341: 111-32 PMID: 26036698. Authors: Melidoni AN, Dyson, MR, McCafferty J
Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)
Publication: Biochem. J. November 2015, 471 (3): 391-401 PMID: 26303525. Authors: Santamaria S, Yamamoto K, Botkjaer K,, Tape C, Dyson MR, McCafferty J, Murphy G, Nagase H
Identification of optimal protein binders through the use of large genetically encoded display libraries
Publication: Curr . Opin. Chem. Biol.. June 2015. 26: 16-24 PMID: 25626152. Authors: McCafferty J, Schofield D
Temporal- and embryonic lineage-dependent regulation of human vascular SMC development by Notch3
Publication: Stem Cells Dev.. December 2014. PMID: 25539150. Authors: Granata A, Bernard WG, Zhao N, McCafferty J, Lilly B, Sinha S
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs tran
Publication: Int J Biol Sci. Jun. June 2014, 10 (7): 702-14 PMID: 25013379. Authors: Huang Y, Benaich N, Tape C, Kwok HF, Murphy G
Development of a ‘mouse and human cross-reactive’ affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy
Publication: Protein Eng. Des. Sel.. March 2014. 27:179 PMID: 24769623. Authors: Kwok HF, Botkjaer KA, Tape CJ, McCafferty J, Murphy G
Phenotypic directed antibody selection
Publication: Chem. Biol.. February 2014, 21 (2): 170 doi:10.1016/j.chembiol.2014.02.004 PMID: 24560164. Authors: McCafferty J
Expression screening in mammalian suspension cells
Publication: Methods Mol. Biol.. October 2013. 1091:143-9 doi:10.1007/978-1-62703-691-7_9 PMID: 24203329. Authors: Chapple SD, Dyson MR
