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A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.
Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AVH, Zanoni P, Landro JA, Barucci N, Zavadoski WJ, Sun Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M, Lund-Katz S, Phillips MC, Tall AR, Kathiresan S, DaSilva-Jardine P, Yates NA, Rader DJ.
FairJourney
Nat Med. 2017 Sep;23(9):1086-1094
A new anti-mesothelin antibody targets selectively the membrane-associated form.
Asgarov K, Balland J, Tirole C, Bouard A, Mougey V, Ramos D, Barroso A, Zangiacomi V, Jary M, Kim S, Gonzalez-Pajuelo M, Royer B, de Haard H, Clark A, Wijdenes J, Borg C.
FairJourney
MAbs. 2017 Apr;9(3):567-577
The INNs and outs of antibody nonproprietary names
Jones TD, Carter PJ, Plückthun A, Vásquez M, Holgate RG, Hötzel I, Popplewell AG, Parren PW, Enzelberger M, Rademaker HJ, Clark MR, Lowe DC, Dahiyat BI, Smith V, Lambert JM, Wu H, Reilly M, Haurum JS, Dübel S, Huston JS, Schirrmann T, Janssen RA,, Steegmaier M, Gross JA, Bradbury AR, Burton DR, Dimitrov DS, Chester KA, Glennie MJ, Davies J, Walker A, Martin S, McCafferty J,, Baker MP
IONTAS
MAbs. January 2016, 8 (1): 1-9
doi: 26716992
Application of phage display to high throughput antibody generation and characterisation
Schofield DJ, Pope AR, Clementel V, Buckell J, Chapple SD, Clarke KF, Conquer JS, Crofts AM, Crowther SR, Dyson MR, Flack G, Griffin GJ, Hooks Y, Howat WJ, Kolb-Kokocinski A, Kunze S, Martin CD, Maslen GL, Mitchell JN, O’Sullivan M, Perera RL, Roake W, Shadbolt SP, Vincent KJ, Warford A, Wilson WE, Xie J, Young JL, McCafferty J
A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing
Parthiban K, Perera RL, Sattar M, Huang Y, Masters E, Griffiths D, Surade S, Leah R, Dyson MR...
IONTAS
mAbs. June 2019
Basics of Antibody Phage Display Technology
Ledsgaard L, Kilstrup M, Karatt-Vellatt A, McCafferty J, Laustsen AH
Phenotypic directed antibody selection
McCafferty J
Selecting antagonistic antibodies that control differentiation through inducible expression in embryonic stem cells
Melidoni AN, Dyson MR, Wormald S, McCafferty J
Detection of weak receptor-ligand interactions using IgM and J-chain-based fusion proteins
Ammann JU, Jahnke M, Dyson MR, Kauffman J, Trowsdale J
IONTAS
Mapping protein interactions by combining antibody affinity maturation and mass spectroscopy
Dyson MR, Zheng Y, Zhang C, Colwill K, Pershad K, Kay BK, Pawson T, McCafferty J
The long and winding road to antibody therapeutics
McCafferty J
Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display
Pershad K, Pavlovic JD, Gräslund S, Nilsson P, Colwill K, Karatt-Vellatt A, Schofield DJ, Dyson MR, Pawson T, Kay BK, McCafferty J
Control of feeding behavious in C. elegans by human G protein-coupled receptors permits screening for agonist-expressing bacteria
Teng MS, Shadbolt P, Fraser AG, Jansen G, McCafferty J
Identification of soluble protein fragments by gene fragmentation and genetic selection
Dyson MR, Perera RL, Shadbolt SP, Biderman L, Bromek K, Murzina NV, McCafferty J
IONTAS
Multiplexed expression and screening for recombinant protein production in mammalian cells
Chapple SD, Crofts AM, Shadbolt SP, McCafferty J, Dyson MR
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome
Taussig MJ, Stoevesandt O, Borrebaeck CA, Bradbury AR, Cahill D, Cambillau C, de Daruvar A, Dübel S, Eichler J, Frank R, Gibson TJ, Gloriam D, Gold L, Herberg FW, Hermjakob H, Hoheisel JD, Joos TO, Kallioniemi O, Koegl M, Konthur Z, Korn B, Kremmer E, Krobitsch S, Landegren U, van der Maarel S, McCafferty J, Muyldermans S, Nygren PA, Palcy S, Plückthun A, Polic B, Przybylski M, Saviranta P, Sawyer A, Sherman DJ, Skerra A, Templin M, Ueffing M, Uhlén M
IONTAS
Temporal- and embryonic lineage-dependent regulation of human vascular SMC development by Notch3
Granata A, Bernard WG, Zhao N, McCafferty J, Lilly B, Sinha S
IONTAS
Stem Cells Dev.. December 2014
doi: 25539150
A simple vector system to improve the performance and utilisation of recombinant antibodies
Martin CD, Rojas G, Mitchell JN, Vincent KJ, Wu J, McCafferty J, Schofield DJ
Resin tissue microarrays: a universal format for immunohistochemistry
Howat WJ, Warford A, Mitchell JN, Clarke KF, Conquer JS, McCafferty J
Production of soluble mammalian proteins in E. coli: identification of protein features that correlate with successful expression
Dyson MR, Shadbolt SP, Vincent KJ, Perera RL, McCafferty J
Beyond natural antibodies: the power of in vitro display technologies
Bradbury AR, Sidhu S, Dübel S, McCafferty J
IONTAS
21390033
Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from ligand binding domain
DiCara DM, Chirgadze DY, Pope AR, Karatt-Vellat A, Winter A, Slavny P, van den Heuvel J, Parthiban K, Holland J, Packman LC, Birchmeier W, Gherardi E, McCafferty J
IONTAS
Scientific Reports. August 2017
doi: 28827556
Development of a ‘mouse and human cross-reactive’ affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy
Kwok HF, Botkjaer KA, Tape CJ, McCafferty J, Murphy G
IONTAS
Protein Eng. Des. Sel.. March 2014. 27:179
doi: 24769623
Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells
Falk R, Falk A, Dyson MR, Melidoni AN, Parthiban K, Young JL, Roake W, McCafferty J
IONTAS
Methods. September 2012, 58 (1): 69-78
doi: 22842086
In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies
Laustsen AH, Karatt-Vellatt A, Masters EW, Arias AS, Pus U, Knudsen C, Oscoz S, Slavny P, Griffiths DT, Luther AM, Leah RA, Lindholm M, Lomonte B, Gutiérrez JM, McCafferty J
IONTAS
30279409
Quantitative Visualization of DNA G-quadruplex Structures in Human Cells
Biffi G, Tannahill D, McCafferty J, Balasubramanian S
IONTAS
Nature Chemistry. January 2013
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs tran
Huang Y, Benaich N, Tape C, Kwok HF, Murphy G
IONTAS
Int J Biol Sci. Jun. June 2014, 10 (7): 702-14
doi: 25013379
Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?
Parthiban K, Perera RL, Sattar M, Huang Y, Masters E, Griffiths D, Surade S, Leah R, Dyson MR...
IONTAS
BMJ Journals. December 2018, 78 (2)
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